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Translocation of Borrelia burgdorferi Surface Lipoprotein OspA Through the Outer Membrane Requires an Unfolded Conformation and Can Initiate at the C-terminus

Borrelia burgdorferi surface lipoproteins are essential to the pathogenesis of Lyme borreliosis, but the mechanisms responsible for their localization are only beginning to emerge. We have previously demonstrated the critical nature of the amino-terminal ‘tether’ domain of the mature lipoprotein for...

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Detalhes bibliográficos
Main Authors: Schulze, Ryan J., Chen, Shiyong, Kumru, Ozan S., Zückert, Wolfram R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999405/
https://ncbi.nlm.nih.gov/pubmed/20398211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07172.x
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