A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents

Chronic infection with the protozoan parasite Trypanosoma cruzi is a major cause of morbidity and mortality in Latin America. Drug treatments for the associated illness, Chagas disease, are toxic and frequently unsuccessful. In a screening effort against the drug target protein farnesyltransferase,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Buckner, Frederick, Yokoyama, Kohei, Lockman, Jeffrey, Aikenhead, Kendra, Ohkanda, Junko, Sadilek, Martin, Sebti, Saïd, Van Voorhis, Wesley, Hamilton, Andrew, Gelb, Michael H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC299928/
https://ncbi.nlm.nih.gov/pubmed/14657358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2535442100
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