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Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3′ nontranslated region

We have proposed a cancer treatment modality based on poliovirus chimeras replicating under the translational control of an internal ribosomal entry site (IRES) derived from human rhinovirus type 2. Insertion of the heterologous IRES causes a neuron-specific propagation deficit and eliminates neurov...

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Bibliografske podrobnosti
Main Authors: Dobrikova, Elena, Florez, Paola, Bradrick, Shelton, Gromeier, Matthias
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC299919/
https://ncbi.nlm.nih.gov/pubmed/14645707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2436464100
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