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Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3′ nontranslated region
We have proposed a cancer treatment modality based on poliovirus chimeras replicating under the translational control of an internal ribosomal entry site (IRES) derived from human rhinovirus type 2. Insertion of the heterologous IRES causes a neuron-specific propagation deficit and eliminates neurov...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC299919/ https://ncbi.nlm.nih.gov/pubmed/14645707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2436464100 |
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