p53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1

Proteasomal degradation of p53 is mediated by two alternative pathways that are either dependent or independent of both Mdm2 and ubiquitin. The ubiquitin-independent pathway is regulated by NAD(P)H: quinone oxidoreductase 1 (NQO1) that stabilizes p53. The NQO1 inhibitor dicoumarol induces ubiquitin-...

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Bibliographic Details
Main Authors: Asher, Gad, Lotem, Joseph, Tsvetkov, Peter, Reiss, Veronica, Sachs, Leo, Shaul, Yosef
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC299908/
https://ncbi.nlm.nih.gov/pubmed/14634213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2436329100
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