p53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1

Proteasomal degradation of p53 is mediated by two alternative pathways that are either dependent or independent of both Mdm2 and ubiquitin. The ubiquitin-independent pathway is regulated by NAD(P)H: quinone oxidoreductase 1 (NQO1) that stabilizes p53. The NQO1 inhibitor dicoumarol induces ubiquitin-...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Asher, Gad, Lotem, Joseph, Tsvetkov, Peter, Reiss, Veronica, Sachs, Leo, Shaul, Yosef
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2003
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14634213/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2436329100
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