Reduced Alzheimer's Disease β-Amyloid Deposition in Transgenic Mice Expressing S-Palmitoylation-Deficient APH1aL and Nicastrin

Sequential cleavage of amyloid precursor protein by β- and γ-secretases generates β-amyloid peptides (Aβ), which accumulate in the brains of patients with Alzheimer's disease. We recently identified S-palmitoylation of two γ-secretase subunits, APH1 and nicastrin. S-Palmitoylation is an essenti...

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Huvudupphovsmän: Meckler, Xavier, Roseman, Jelita, Das, Pritam, Cheng, Haipeng, Pei, Susan, Keat, Marcia, Kassarjian, Breanne, Golde, Todd E., Parent, Angèle T., Thinakaran, Gopal
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2010
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2999009/
https://ncbi.nlm.nih.gov/pubmed/21123562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4436-10.2010
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