Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast

The repair of chromosomal double-strand breaks (DSBs) can be accomplished through homologous recombination in most organisms. We report here that exogenous oligonucleotides can efficiently target for repair a single DSB induced in a chromosome of yeast. The efficiency of recombinational targeting le...

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Hauptverfasser: Storici, Francesca, Durham, Christopher L., Gordenin, Dmitry A., Resnick, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC299876/
https://ncbi.nlm.nih.gov/pubmed/14630945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2036296100
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