Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: Evolutionarily conserved but highly recombinogenic

Common fragile sites are regions that show elevated susceptibility to DNA damage, leading to alterations that can contribute to cancer development. FRA3B, located at chromosome region 3p14.2, is the most frequently expressed human common fragile site, and allelic losses at FRA3B have been observed i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Matsuyama, Ayumi, Shiraishi, Takeshi, Trapasso, Francesco, Kuroki, Tamotsu, Alder, Hansjuerg, Mori, Masaki, Huebner, Kay, Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299872/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14630947/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2336256100
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