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Rapid Ca(2+)-dependent decrease of protein ubiquitination at synapses

Protein ubiquitination has been implicated in the regulation of axonal growth and synaptic plasticity as well as in the pathogenesis of neurodegenerative diseases. Here we show that depolarization-dependent Ca(2+) influx into synaptosomes produces a global, rapid (range of seconds), and reversible d...

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Detalhes bibliográficos
Main Authors: Chen, Hong, Polo, Simona, Di Fiore, Pier Paolo, De Camilli, Pietro V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC299851/
https://ncbi.nlm.nih.gov/pubmed/14657369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2136625100
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