Matriptase-2- and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression

Hemojuvelin (HJV) is an important regulator of iron metabolism. Membrane-anchored HJV up-regulates expression of the iron regulatory hormone, hepcidin, through the bone morphogenic protein (BMP) signaling pathway by acting as a BMP co-receptor. HJV can be cleaved by the furin family of proprotein co...

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Bibliographic Details
Main Authors: Maxson, Julia E., Chen, Juxing, Enns, Caroline A., Zhang, An-Sheng
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998150/
https://ncbi.nlm.nih.gov/pubmed/20937842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183160
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