MAP/ERK Kinase Kinase 1 (MEKK1) Mediates Transcriptional Repression by Interacting with Polycystic Kidney Disease-1 (PKD1) Promoter-bound p53 Tumor Suppressor Protein

Mitogen-activated protein kinase (MAPK) cascades regulate a wide variety of cellular processes that ultimately depend on changes in gene expression. We have found a novel mechanism whereby one of the key MAP3 kinases, Mekk1, regulates transcriptional activity through an interaction with p53. The tum...

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Detaylı Bibliyografya
Asıl Yazarlar: Islam, M. Rafiq, Jimenez, Tamara, Pelham, Christopher, Rodova, Marianna, Puri, Sanjeev, Magenheimer, Brenda S., Maser, Robin L., Widmann, Christian, Calvet, James P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Gene Regulation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998141/
https://ncbi.nlm.nih.gov/pubmed/20923779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.145284
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