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Overexpression of PKD1 Causes Polycystic Kidney Disease
The pathogenetic mechanisms underlying autosomal dominant polycystic kidney disease (ADPKD) remain to be elucidated. While there is evidence that Pkd1 gene haploinsufficiency and loss of heterozygosity can cause cyst formation in mice, paradoxically high levels of Pkd1 expression have been detected...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367205/ https://ncbi.nlm.nih.gov/pubmed/16449663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1538-1548.2006 |
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