Overexpression of PKD1 Causes Polycystic Kidney Disease

The pathogenetic mechanisms underlying autosomal dominant polycystic kidney disease (ADPKD) remain to be elucidated. While there is evidence that Pkd1 gene haploinsufficiency and loss of heterozygosity can cause cyst formation in mice, paradoxically high levels of Pkd1 expression have been detected...

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Hauptverfasser: Thivierge, Caroline, Kurbegovic, Almira, Couillard, Martin, Guillaume, Richard, Coté, Olivier, Trudel, Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367205/
https://ncbi.nlm.nih.gov/pubmed/16449663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1538-1548.2006
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