Characterization of FdmV as an Amide Synthetase for Fredericamycin A Biosynthesis in Streptomyces griseus ATCC 43944

Fredericamycin (FDM) A is a pentadecaketide natural product that features an amide linkage. Analysis of the fdm cluster from Streptomyces griseus ATCC 43944, however, failed to reveal genes encoding the types of amide synthetases commonly seen in natural product biosynthesis. Here, we report in vivo...

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Main Authors: Chen, Yihua, Wendt-Pienkowski, Evelyn, Ju, Jianhua, Lin, Shuangjun, Rajski, Scott R., Shen, Ben
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
主題:
Enzymology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998092/
https://ncbi.nlm.nih.gov/pubmed/20926388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.147744
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