Identification of Residue-to-residue Contact between a Peptide Ligand and Its G Protein-coupled Receptor Using Periodate-mediated Dihydroxyphenylalanine Cross-linking and Mass Spectrometry

Fundamental knowledge about how G protein-coupled receptors and their ligands interact is important for understanding receptor-ligand binding and the development of new drug discovery strategies. We have used cross-linking and tandem mass spectrometry analyses to investigate the interaction of the N...

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Main Authors: Umanah, George K. E., Huang, Liyin, Ding, Fa-xiang, Arshava, Boris, Farley, Adam R., Link, Andrew J., Naider, Fred, Becker, Jeffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998077/
https://ncbi.nlm.nih.gov/pubmed/20923758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149500
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