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Targeting BAFF in autoimmunity
BAFF and APRIL are TNF-like cytokines that support survival and differentiation of B cells. The early appreciation that overexpression of BAFF leads to B cell expansion and a lupus-like syndrome in mice, and the demonstration that BAFF inhibition delays lupus onset in spontaneous mouse models of SLE...
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| Hovedforfatter: | |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997938/ https://ncbi.nlm.nih.gov/pubmed/20970975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2010.09.010 |
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