Over-expression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor

OBJECTIVES: The objective of this study is to elucidate the mechanism of TGF-β1 over-expression in prostate cancer cells. METHODS: Malignant (PC3, DU145) and benign (RWPE1, BPH1) prostate epithelial cells were used. Phosphatase activity was measured using a commercial kit. Recruitment of the regulat...

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Detaylı Bibliyografya
Asıl Yazarlar: Yu, Nengwang, Kozlowski, James M., Park, Irwin I., Chen, Lin, Zhang, Qiang, Xu, Danfeng, Doll, Jennifer A., Crawford, Susan E., Brendler, Charles B., Lee, Chung
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997920/
https://ncbi.nlm.nih.gov/pubmed/21030067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.urology.2010.03.061
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