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Cross-reactivityvirtual profiling of the human kinome by X-React(KIN) – a Chemical Systems Biology approach

Many drug candidates fail in clinical development due to their insufficient selectivity that may cause undesired side effects. Therefore, modern drug discovery is routinely supported by computational techniques, which can identify alternate molecular targets with a significant potential for cross-re...

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書目詳細資料
Main Authors: Brylinski, Michal, Skolnick, Jeffrey
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997910/
https://ncbi.nlm.nih.gov/pubmed/20958088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp1002976
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