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Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1
The use of histone deacetylase (HDAC) inhibitors has revealed an essential role for deacetylation in transcription of IFN-responsive genes. The HDAC1 protein associates with both signal transducer and activator of transcription (STAT) 1 and STAT2, and IFN-α stimulation induces deacetylation of histo...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2003
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC299790/ https://ncbi.nlm.nih.gov/pubmed/14645718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2433987100 |
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