Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity

Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was essential for transcriptional induction of IFN-stimulated genes (ISG). Inhibition of HDAC function led to global impairment of ISG expression, with little effect on basal expression. HDAC function was not r...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Chang, Hao-Ming, Paulson, Matthew, Holko, Michelle, Rice, Charles M., Williams, Bryan R. G., Marié, Isabelle, Levy, David E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC470717/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15210966/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400567101
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