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Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was essential for transcriptional induction of IFN-stimulated genes (ISG). Inhibition of HDAC function led to global impairment of ISG expression, with little effect on basal expression. HDAC function was not r...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC470717/ https://ncbi.nlm.nih.gov/pubmed/15210966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400567101 |
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