Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity

Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was essential for transcriptional induction of IFN-stimulated genes (ISG). Inhibition of HDAC function led to global impairment of ISG expression, with little effect on basal expression. HDAC function was not r...

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Bibliographic Details
Main Authors: Chang, Hao-Ming, Paulson, Matthew, Holko, Michelle, Rice, Charles M., Williams, Bryan R. G., Marié, Isabelle, Levy, David E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC470717/
https://ncbi.nlm.nih.gov/pubmed/15210966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400567101
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