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Morphine-induced endocytosis of the mu opioid receptor in a novel knock in mouse enhances analgesia and reduces tolerance and dependence
Chronic pain remains one of the most widespread and under treated medical conditions. Opioid drugs, such as morphine, are some of the most effective analgesics available. However, their utility for the treatment of chronic pain are limited by side effects including tolerance and dependence. Morphine...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997702/ https://ncbi.nlm.nih.gov/pubmed/18207746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2007.12.057 |
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