Morphine-induced endocytosis of the mu opioid receptor in a novel knock in mouse enhances analgesia and reduces tolerance and dependence

Chronic pain remains one of the most widespread and under treated medical conditions. Opioid drugs, such as morphine, are some of the most effective analgesics available. However, their utility for the treatment of chronic pain are limited by side effects including tolerance and dependence. Morphine...

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Main Authors: Kim, Joseph A., Bartlett, Selena, He, Li, Nielsen, Carsten K., Chang, Amy M., Kharazia, Viktor, Waldhoer, Maria, Ou, Chrissi J., Taylor, Stacy, Ferwerda, Madeline, Cado, Dragana, Whistler, Jennifer L.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997702/
https://ncbi.nlm.nih.gov/pubmed/18207746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2007.12.057
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