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Small molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer
The zinc fingers of the HIV-1 nucleocapsid protein, NCp7, are prime targets for antiretroviral therapeutics. Here we show that S-acyl-2-mercaptobenzamide thioester (SAMT) chemotypes inhibit HIV by modifying the NCp7 region of Gag in infected cells, thereby blocking Gag processing and reducing infect...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2997617/ https://ncbi.nlm.nih.gov/pubmed/20953192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.456 |
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