Efficient Gene Transfer Into the Mouse Lung by Fetal Intratracheal Injection of rAAV2/6.2

Fetal gene therapy is one of the possible new therapeutic strategies for congenital or perinatal diseases with high mortality or morbidity. We developed a novel delivery strategy to inject directly into the fetal mouse trachea. Intratracheal (i.t.) injection at embryonic day 18 (E18) was more effici...

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Main Authors: Carlon, Marianne, Toelen, Jaan, Van der Perren, Anke, Vandenberghe, Luk H, Reumers, Veerle, Sbragia, Lourenço, Gijsbers, Rik, Baekelandt, Veerle, Himmelreich, Uwe, Wilson, James M, Deprest, Jan, Debyser, Zeger
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997580/
https://ncbi.nlm.nih.gov/pubmed/20664525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.153
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