Immunological Ignorance Allows Long-Term Gene Expression After Perinatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer to Murine Airways

Gene therapy of the lung has the potential to treat life-threatening diseases such as cystic fibrosis and α(1)-antitrypsin or surfactant deficiencies. A major hurdle for successful gene therapy is the development of an immune response against the transgene and/or viral vector. We hypothesized that b...

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Detalhes bibliográficos
Main Authors: Carlon, Marianne S., Vidović, Dragana, Dooley, James, da Cunha, Marina Mori, Maris, Michael, Lampi, Youlia, Toelen, Jaan, Van den Haute, Chris, Baekelandt, Veerle, Deprest, Jan, Verbeken, Erik, Liston, Adrian, Gijsbers, Rik, Debyser, Zeger
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064737/
https://ncbi.nlm.nih.gov/pubmed/24548076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.196
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