XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum

BACKGROUND & AIMS: The transition of gastric epithelial mucous neck cells (NCs) to digestive-enzyme–secreting zymogenic cells (ZCs) involves an increase in rough endoplasmic reticulum (rER) and formation of many large secretory vesicles. The transcription factor MIST1 is required for granulogene...

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Main Authors: Huh, Won Jae, Esen, Emel, Geahlen, Jessica H., Bredemeyer, Andrew J., Lee, Ann-Hwee, Shi, Guanglu, Konieczny, Stephen F., Glimcher, Laurie H., Mills, Jason C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997137/
https://ncbi.nlm.nih.gov/pubmed/20816838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.08.050
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