Abasic sites preferentially form at regions undergoing DNA replication

We investigated whether apurinic/apyrimidinic (AP/abasic) sites were more frequent in regions of DNA replication in cells and whether their number increased during oxidative stress. DNA fiber spreading and fluorescent immunostaining were used to detect areas of DNA replication and sites of AP lesion...

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Bibliographic Details
Main Authors: Chastain, Paul D., Nakamura, Jun, Rao, Shangbang, Chu, Haitao, Ibrahim, Joseph G., Swenberg, James A., Kaufman, David G.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2010
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996904/
https://ncbi.nlm.nih.gov/pubmed/20511393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-145276
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