LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity

Removal of sialic acid from glycoconjugates on the surface of monocytes enhances their response to bacterial LPS. We tested the hypothesis that endogenous sialidase activity creates a permissive state for LPS-induced cytokine production in human monocyte-derived DCs. Of the four genetically distinct...

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Autors principals: Stamatos, Nicholas M., Carubelli, Ivan, van de Vlekkert, Diantha, Bonten, Erik J., Papini, Nadia, Feng, Chiguang, Venerando, Bruno, d'Azzo, Alessandra, Cross, Alan S., Wang, Lai-Xi, Gomatos, Peter J.
Format: Artigo
Idioma:Inglês
Publicat: Society for Leukocyte Biology 2010
Matèries:
Inflammation, Extracellular Mediators, & Effector Molecules
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996894/
https://ncbi.nlm.nih.gov/pubmed/20826611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1209776
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