LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity

Removal of sialic acid from glycoconjugates on the surface of monocytes enhances their response to bacterial LPS. We tested the hypothesis that endogenous sialidase activity creates a permissive state for LPS-induced cytokine production in human monocyte-derived DCs. Of the four genetically distinct...

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Main Authors: Stamatos, Nicholas M., Carubelli, Ivan, van de Vlekkert, Diantha, Bonten, Erik J., Papini, Nadia, Feng, Chiguang, Venerando, Bruno, d'Azzo, Alessandra, Cross, Alan S., Wang, Lai-Xi, Gomatos, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Leukocyte Biology 2010
Fag:
Inflammation, Extracellular Mediators, & Effector Molecules
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996894/
https://ncbi.nlm.nih.gov/pubmed/20826611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1209776
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