Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import

Several proteins of the mitochondrial intermembrane space are targeted by internal targeting signals. A class of such proteins with α-helical hairpin structure bridged by two intramolecular disulfides is trapped by a Mia40-dependent oxidative process. Here, we describe the oxidative folding mechanis...

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Autores principales: Banci, Lucia, Bertini, Ivano, Cefaro, Chiara, Cenacchi, Lucia, Ciofi-Baffoni, Simone, Felli, Isabella Caterina, Gallo, Angelo, Gonnelli, Leonardo, Luchinat, Enrico, Sideris, Dionisia, Tokatlidis, Kostas
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Physical Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996643/
https://ncbi.nlm.nih.gov/pubmed/21059946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010095107
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