A novel intermembrane space–targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding

Mia40 imports Cys-containing proteins into the mitochondrial intermembrane space (IMS) by ensuring their Cys-dependent oxidative folding. In this study, we show that the specific Cys of the substrate involved in docking with Mia40 is substrate dependent, the process being guided by an IMS-targeting...

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Main Authors: Sideris, Dionisia P., Petrakis, Nikos, Katrakili, Nitsa, Mikropoulou, Despina, Gallo, Angelo, Ciofi-Baffoni, Simone, Banci, Lucia, Bertini, Ivano, Tokatlidis, Kostas
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2009
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806287/
https://ncbi.nlm.nih.gov/pubmed/20026652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200905134
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