Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.
Four alanine-based peptides were designed, synthesized, and tested by circular dichroism for alpha-helix formation in H2O. Each peptide has three glutamic/lysine residue pairs, is 16 or 17 amino acids long, and has blocked alpha-NH2 and alpha-COOH groups. In one set of peptides ("i+4"), the glutamic...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1987
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299658/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3122208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.24.8898 |
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