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Reciprocal Regulation of 11β-Hydroxysteroid Dehydrogenase 1 and Glucocorticoid Receptor Expression by Dexamethasone Inhibits Human Coronary Artery Smooth Muscle Cell Proliferation In Vitro
The actions of glucocorticoids are mediated, in part, by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which amplifies their effects at the pre-receptor level by converting cortisone to cortisol. Glucocorticoids, such as dexamethasone, inhibit vascular smooth muscle cell proliferation; however, the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2996480/ https://ncbi.nlm.nih.gov/pubmed/20922465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-010-0592-5 |
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