Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformation

The v-Crk oncogene product consists of two protein interaction modules, a Src homology 2 (SH2) domain and an SH3 domain. Overexpression of CrkI, the cellular homolog of v-Crk, transforms mouse fibroblasts, and elevated CrkI expression is observed in several human cancers. The SH2 and SH3 domains of...

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Bibliographic Details
Main Authors: Zheng, Ji, Machida, Kazuya, Antoku, Susumu, Ng, Khong Ying, Claffey, Kevin P., Mayer, Bruce J.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996469/
https://ncbi.nlm.nih.gov/pubmed/20729917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.369
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