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Structure and folding of a designed knotted protein

A very small number of natural proteins have folded configurations in which the polypeptide backbone is knotted. Relatively little is known about the folding energy landscapes of such proteins, or how they have evolved. We explore those questions here by designing a unique knotted protein structure....

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Detalhes bibliográficos
Main Authors: King, Neil P., Jacobitz, Alex W., Sawaya, Michael R., Goldschmidt, Lukasz, Yeates, Todd O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996448/
https://ncbi.nlm.nih.gov/pubmed/21068371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007602107
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