A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

Cell-specific expression of the insulin gene is controlled by cis-acting DNA sequences located within approximately equal to 350 base pairs of the 5' flanking DNA immediately upstream from the transcription start site. Using synthetic oligonucleotides, we have constructed a systematic series of...

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Hlavní autoři: Karlsson, O, Edlund, T, Moss, J B, Rutter, W J, Walker, M D
Médium: Artigo
Jazyk:Inglês
Vydáno: 1987
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC299642/
https://ncbi.nlm.nih.gov/pubmed/3321054
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