A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

Cell-specific expression of the insulin gene is controlled by cis-acting DNA sequences located within approximately equal to 350 base pairs of the 5' flanking DNA immediately upstream from the transcription start site. Using synthetic oligonucleotides, we have constructed a systematic series of bloc...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Karlsson, O, Edlund, T, Moss, J B, Rutter, W J, Walker, M D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC299642/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3321054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.24.8819
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