Genetic manipulation of AML1-ETO–induced expansion of hematopoietic precursors in a Drosophila model

Among mutations in human Runx1/AML1 transcription factors, the t(8;21)(q22;q22) genomic translocation that creates an AML1-ETO fusion protein is implicated in etiology of the acute myeloid leukemia. To identify genes and components associated with this oncogene we used Drosophila as a genetic model....

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Detalhes bibliográficos
Main Authors: Sinenko, Sergey A., Hung, Tony, Moroz, Tatiana, Tran, Quynh-Minh, Sidhu, Sohrab, Cheney, Matthew D., Speck, Nancy A., Banerjee, Utpal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996118/
https://ncbi.nlm.nih.gov/pubmed/20688956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-276998
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