p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell

BACKGROUND: Non-small-cell lung carcinomas (NSCLCs) exhibit poor prognosis and are usually resistant to conventional chemotherapy. Absence of p21WAF1/CIP1, a cyclin-dependent kinase (cdk) inhibitor, has been linked to drug resistance in many in vitro cellular models. RNA activation (RNAa) is a trans...

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Main Authors: Wei, Junxia, Zhao, Jiang, Long, Min, Han, Yuan, Wang, Xi, Lin, Fang, Ren, Jihong, He, Ting, Zhang, Huizhong
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995802/
https://ncbi.nlm.nih.gov/pubmed/21087528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-632
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