Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells

BACKGROUND: The immunoregulatory enzyme indoleamine 2,3-dioxygenase, which catalyzes the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients with acute myeloid leukemia, resulting in the inhibition of T-cell proliferation and the induction of regulatory T cells...

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Autori principali: Curti, Antonio, Trabanelli, Sara, Onofri, Chiara, Aluigi, Michela, Salvestrini, Valentina, Ocadlikova, Darina, Evangelisti, Cecilia, Rutella, Sergio, De Cristofaro, Raimondo, Ottaviani, Emanuela, Baccarani, Michele, Lemoli, Roberto M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995559/
https://ncbi.nlm.nih.gov/pubmed/20801903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.025924
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