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Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

Insulin resistance is the best predictor for the development of diabetes in offspring of type 2 diabetic patients, but the mechanism responsible for it remains unknown. Recent studies have demonstrated increased intramyocellular lipid, decreased mitochondrial ATP synthesis, and decreased mitochondri...

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Detalles Bibliográficos
Main Authors: Befroy, Douglas E., Petersen, Kitt Falk, Dufour, Sylvie, Mason, Graeme F., de Graaf, Robin A., Rothman, Douglas L., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995532/
https://ncbi.nlm.nih.gov/pubmed/17287462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db06-0783
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