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Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformations
Enzymes generally are thought to derive their functional activity from conformational motions. The limited chemical variation in RNA suggests that such structural dynamics may play a particularly important role in RNA function. Minimal hammerhead ribozymes are known to cleave efficiently only in ∼10...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995402/ https://ncbi.nlm.nih.gov/pubmed/20921269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1829110 |
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