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Minimal Hammerhead Ribozymes with Uncompromised Catalytic Activity
We report here that a single additional trans-Hoogsteen base-pairing interaction in the minimal hammerhead ribozyme transforms an RNA sequence possessing typically modest catalytic activity into one possessing greatly enhanced catalytic activity that is instead typical of full-length natural hammerh...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4464905/ https://ncbi.nlm.nih.gov/pubmed/25981451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.05.005 |
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