Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication

The E3 ubiquitin ligase Rad18 guides DNA Polymerase eta (Polη) to sites of replication fork stalling and mono-ubiquitinates proliferating cell nuclear antigen (PCNA) to facilitate binding of Y family trans-lesion synthesis (TLS) DNA polymerases during TLS. However, it is unclear exactly how Rad18 is...

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Detalhes bibliográficos
Main Authors: Day, Tovah A., Palle, Komariah, Barkley, Laura R., Kakusho, Naoko, Zou, Ying, Tateishi, Satoshi, Verreault, Alain, Masai, Hisao, Vaziri, Cyrus
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995173/
https://ncbi.nlm.nih.gov/pubmed/21098111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201006043
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