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Error correction of next-generation sequencing data and reliable estimation of HIV quasispecies
Next-generation sequencing technologies can be used to analyse genetically heterogeneous samples at unprecedented detail. The high coverage achievable with these methods enables the detection of many low-frequency variants. However, sequencing errors complicate the analysis of mixed populations and...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995073/ https://ncbi.nlm.nih.gov/pubmed/20671025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq655 |
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