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Specific inhibition of pathogenic receptor tyrosine kinase activation by its transmembrane domain

The transmembrane (TM) domains of receptor tyrosine kinases (RTKs) are believed to be important players in RTK signal transduction. However, the degree of specificity and promiscuity of RTK TM domain lateral interactions in mammalian membranes has not been assessed in detail in the literature. A tec...

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Main Authors: He, Lijuan, Shobnam, Nadia, Hristova, Kalina
格式: Artigo
語言:Inglês
出版: 2010
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994959/
https://ncbi.nlm.nih.gov/pubmed/20713021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2010.08.007
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