Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors

BACKGROUND: Recent findings indicate that inhibitors of fatty acid amide hydrolase (FAAH) counteract the rewarding effects of nicotine in rats. FAAH inhibition increases levels of several endogenous substances in the brain, including the endocannabinoid anandamide and the non-cannabinoid fatty-acid...

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Autori principali: Mascia, Paola, Pistis, Marco, Justinova, Zuzana, Panlilio, Leigh V., Luchicchi, Antonio, Lecca, Salvatore, Scherma, Maria, Fratta, Walter, Fadda, Paola, Barnes, Chanel, Redhi, Godfrey H., Yasar, Sevil, Le Foll, Bernard, Tanda, Gianluigi, Piomelli, Daniele, Goldberg, Steven R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994947/
https://ncbi.nlm.nih.gov/pubmed/20801430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2010.07.009
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