pp32 (ANP32A) Expression Inhibits Pancreatic Cancer Cell Growth and Induces Gemcitabine Resistance by Disrupting HuR Binding to mRNAs

The expression of protein phosphatase 32 (PP32, ANP32A) is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1), a predictive marker for gemcitabine response. In pancreatic cancer cells, exogenous overexpression of pp32 inhibited cell growth, supporting its long...

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Bibliographic Details
Main Authors: Williams, Timothy K., Costantino, Christina L., Bildzukewicz, Nikolai A., Richards, Nathan G., Rittenhouse, David W., Einstein, Lisa, Cozzitorto, Joseph A., Keen, Judith C., Dasgupta, Abhijit, Gorospe, Myriam, Gonye, Gregory E., Yeo, Charles J., Witkiewicz, Agnieszka K., Brody, Jonathan R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994932/
https://ncbi.nlm.nih.gov/pubmed/21152064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015455
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