pp32 (ANP32A) Expression Inhibits Pancreatic Cancer Cell Growth and Induces Gemcitabine Resistance by Disrupting HuR Binding to mRNAs

The expression of protein phosphatase 32 (PP32, ANP32A) is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1), a predictive marker for gemcitabine response. In pancreatic cancer cells, exogenous overexpression of pp32 inhibited cell growth, supporting its long...

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Detalhes bibliográficos
Main Authors: Williams, Timothy K., Costantino, Christina L., Bildzukewicz, Nikolai A., Richards, Nathan G., Rittenhouse, David W., Einstein, Lisa, Cozzitorto, Joseph A., Keen, Judith C., Dasgupta, Abhijit, Gorospe, Myriam, Gonye, Gregory E., Yeo, Charles J., Witkiewicz, Agnieszka K., Brody, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2994932/
https://ncbi.nlm.nih.gov/pubmed/21152064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015455
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